Sure, we've seen that with Edwards, and with Koji.
The board was often much crabby about Edwards getting used as much as he was, given his wildness; it may be that his numbers versus lefties contributed to that? (If you put in Strop or Rondon, and know you're going to yank them the minute a lefty comes up, maybe use Edwards instead so you don't, and can save or rest lefties?)
As pertain to Cishek, though, his numbers versus lefties are worse than Strop or career Rondon. So unless Maddon decides to change how he manages, we can assume that Cishek will be as or more prone to getting lifted when a lefty comes up that has been true with Strop or Rondon.
Rondon's career numbers are better than Cishek, but they were kinda poor this last year. Worse overall, of course, but particularly so versus lefties. I wonder whether that factored in at all in the decision to non-tender him? Maybe Maddon just knew he was never going to trust Hector versus lefties, and he's hoping that this year he can be more trusting of Strop and Cishek as well as Edwards versus lefties?
Cubs lefties actually aren't that split-strong versus lefties. Wilson's numbers were obviously terrible versus everybody, but his 2017 numbers versus lefties were really bad. Duensing didn't have much split either, and his overall OPS versus lefties doesn't look any or much better than using Cishek versus lefties, certainly not as good as Strop or Edwards. Montgomery isn't much of a splits guy, either.