There have been 2,419 hitters to have at least 2,000 career plate appearances since 1900. Jeff Mathis has a wRC+ of 50, which ranks 2,412th. He's arguably the worst hitting position player ever. You don't have to be scared of attacking the zone when he's up.
I just don't get continuing to try to hit the edge of the zone that the umpire clearly wasn't giving him. Just trust your stuff and throw the ball in the middle of the strike zone.