I think it's doubtful that they'll lose 100 games again. It is really hard to lose 100 games. The only way they did it last year was by using only two major league starting pitchers in August, only one (back end) major league starting pitcher in September, and an awful bullpen that they're working to fix with Fujikawa and maybe Grilli.
On paper, this is probably a ~70 win team, just like the team they started last season with. Maybe they'll do the same dumping of starting pitching in 2013...but at the very least, they should let Samardzija take his last 4-5 starts. And just improving the bullpen to the point where they're 25th best (instead of dead last by a wide margin) will keep them from losing 100.
Also, we still have over 2 months until pitchers and catchers report. I'm not completely giving up hope that they'll add a hitter and a longer term starting pitcher (someone like Edwin Jackson) before the season starts.