Reagan was elected Governor in 1966 and served 2 terms thru 1974/5. Then elected President in 1980.
Nixon out of power after VP ended in 1960-61 and elected President in 1968.
In both cases, they were very active in the interim periods supporting other candidates, raising money for them, and the like.
DeSantis, on the other hand, doesnt seem to like being around people much and doing basic retail politics and, therefore, might actually have a problem being out of office. Is he capable of ingratiating himself to the political environment nationally when out of office (or anytime for that matter)? Perhaps not.